In The Spectacular Spider-Man, Harry dies, but he is resurrected in The Amazing Spider-Man 2 and took the serum.

In an effort to validate his father’s wrong, Osborn took the Globulin Green or serum, a substance that was believed to improve the physical qualities of anyone who used it.

However, Harry was unaware that this molecular composition came at a high cost, one that lost his sanity.

During a nighttime party with Fisk, he was attacked by a Russian assassin who dressed as a bartender in order to poison Harry to death. His best buddy Peter covertly discovered the bartender when he “accidentally” bumped into him, saving Harry’s life.

Spiderman’s DNA has the power to recover anyone instantaneously, making his blood essential for Harry’s goblin disease.

Harry discovers a secret room after being rejected by Spiderman’s blood. A secret room packed with hidden weaponry, including a green outfit that heals its bearer quickly.

This serum not only gave Norman all of the abilities of the other Spiders, but it also transformed him into a half-spider beast.