As a young man, Lai Mohammed was employed as a Graduate Assistant at the University of Illorin. He served at the university until he moved to the Nigerian Ports Authority between 1978 and 1987, serving in portfolios of Senior PRO, Principal PRO, and Assistant Chief PRO. Between the years 1987 and 1988, he worked in the capacity of Corporate Secretary at the Nigerian Ports Authority.
In 1989, following his call to Bar, Alhaji Lai Mohammed became the co-founder and actively principal partner at EDU & MOHAMMED (ATTORNEYS-AT-LAW) from 1989 to 1999. In addition to these, he is a recognized fellow of the Nigerian Institute of Public Relations (NIPR).
His career in law did not limit him to the corners of the courtroom. Still, the minister grew in his career and was once the Chairman of Limited company Optmedia, a subsidiary of Afromedia Plc, from 18 December 2008. Subsequently, he served as a Director with the mother company, Afromedia Plc, since May 2011.
