In March 2004, Murphy opened his first solo enterprise, Landmarc, in Tribeca. Over the next fifteen years, his restaurants expanded to include: Ditch Plains in the West Village (2006), Landmarc in the Time Warner Center (2007-2019), Kingside at the Viceroy Hotel (2003), and Grey Salt at the Seminole Hard Rock Hotel and Casino Tampa in 2015.
In 2019 it was announced he’d partner with Levent Veziroglu for Grisini Food Hall and Coffee Shops at New Jersey’s American Dream.
